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Southwest Pulmonary and Critical Care Fellowships

Pulmonary Journal Club

(Click on title to be directed to posting, most recent listed first)

May 2017 Phoenix Pulmonary/Critical Care Journal Club
October 2015 Phoenix Pulmonary Journal Club: Lung Volume Reduction
September 2015 Tucson Pulmonary Journal Club: Genomic Classifier
   for Lung Cancer
April 2015 Phoenix Pulmonary Journal Club: Endo-Bronchial Ultrasound in
   Diagnosing Tuberculosis
February 2015 Tucson Pulmonary Journal Club: Fibrinolysis for PE
January 2015 Tucson Pulmonary Journal Club: Withdrawal of Inhaled
    Glucocorticoids in COPD
January 2015 Phoenix Pulmonary Journal Club: Noninvasive Ventilation In 
   Acute Respiratory Failure
September 2014 Tucson Pulmonary Journal Club: PANTHEON Study
June 2014 Tucson Pulmonary Journal Club: Pirfenidone in Idiopathic
   Pulmonary Fibrosis
September 2014 Phoenix Pulmonary Journal Club: Inhaled Antibiotics
August 2014 Phoenix Pulmonary Journal Club: The Use of Macrolide
   Antibiotics in Chronic Respiratory Disease
June 2014 Phoenix Pulmonary Journal Club: New Therapies for IPF
   and EBUS in Sarcoidosis
March 2014 Phoenix Pulmonary Journal Club: Palliative Care
February 2014 Phoenix Pulmonary Journal Club: Smoking Cessation
January 2014 Pulmonary Journal Club: Interventional Guidelines
December 2013 Tucson Pulmonary Journal Club: Hypothermia
December 2013 Phoenix Pulmonary Journal Club: Lung Cancer
   Screening
November 2013 Tucson Pulmonary Journal Club: Macitentan
November 2013 Phoenix Pulmonary Journal Club: Pleural Catheter
   Infection
October 2013 Tucson Pulmonary Journal Club: Tiotropium Respimat 
October 2013 Pulmonary Journal Club: Pulmonary Artery
   Hypertension
September 2013 Pulmonary Journal Club: Riociguat; Pay the Doctor
August 2013 Pulmonary Journal Club: Pneumococcal Vaccine
   Déjà Vu
July 2013 Pulmonary Journal Club
June 2013 Pulmonary Journal Club
May 2013 Pulmonary Journal Club
March 2013 Pulmonary Journal Club
February 2013 Pulmonary Journal Club
January 2013 Pulmonary Journal Club
December 2012 Pulmonary Journal Club
November 2012 Pulmonary Journal Club
October 2012 Pulmonary Journal Club
September 2012 Pulmonary Journal Club
August 2012 Pulmonary Journal Club
June 2012 Pulmonary Journal Club
June 2012 Pulmonary Journal Club
May 2012 Pulmonary Journal Club
April 2012 Pulmonary Journal Club
March 2012 Pulmonary Journal Club
February 2012 Pulmonary Journal Club
January 2012 Pulmonary Journal Club
December 2011 Pulmonary/Sleep Journal Club
October, 2011 Pulmonary Journal Club
September, 2011 Pulmonary Journal Club
August, 2011 Pulmonary Journal Club
July 2011 Pulmonary Journal Club
May, 2011 Pulmonary Journal Club
April, 2011 Pulmonary Journal Club
February 2011 Pulmonary Journal Club 
January 2011 Pulmonary Journal Club 
December 2010 Pulmonary Journal Club

 

Both the Phoenix Good Samaritan/VA and the Tucson University of Arizona fellows previously had a periodic pulmonary journal club in which current or classic pulmonary articles were reviewed and discussed. A brief summary was written of each discussion describing thearticle and the strengths and weaknesses of each article.

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Entries in cancer screening (1)

Saturday
Jun292013

June 2013 Pulmonary Journal Club

National Lung Screening Trial Research Team, Church TR, Black WC, Aberle DR, Berg CD, Clingan KL, Duan F, Fagerstrom RM, Gareen IF, Gierada DS, Jones GC, Mahon I, Marcus PM, Sicks JD, Jain A, Baum S. Results of initial low-dose computed tomographic screening for lung cancer. N Engl J Med. 2013;368(21):1980-91. [CrossRef]  [PubMed]

This paper serves as a follow up on the results of the first round of testing using low dose computed tomography in screening for lung cancer.  A full review on the initial results can be referenced from the August 2011 Pulmonary Journal Club (1).

The study was performed at 33 centers from 2002 – 2004. A total of 53454 patients were enrolled. Inclusion criteria were age 55-74 and a 30 pack-year smoking history. All patients were randomized to receive either low dose screening CT scan (LDCT) or a chest x-ray.

The results of the first year of screening showed that the LDCT group had 7191 patients with a positive result. Out of these 7191 patients 270 patients (3.75%) were diagnosed with lung cancer. In the chest x-ray group a total of 2387 patients had a positive result and 136 patients (5.7%) were diagnosed with lung cancer. There were more stage 1A cancers diagnosed in the LDCT group (132 patients) compared to the chest x-ray group (46 patients).

The results of the study support that there is a higher prevalence in stage 1A lung cancer within the LDCT screening arm. However this comes at a cost of a substantial number of false positives which often result in additional tests, procedures and costs. In addition when we look at the overall prevalence of lung cancer between the LDCT and chest x-ray groups the difference is only 1% in the LDCT group compared to 0.7% in the chest x-ray group.  

Further information as the screening process continues will be needed to see if CT scanning is cost effective in screening for lung cancer.

Manoj Mathew, MD MCCM, FCCP

Reference

  1. Mathew M. August 2011 pulmonary journal club. Southwest J Pulm Crit Care. 2011;3:52-3.

Reference as: Mathew M. June 2013 pulmonary journal club. Southwest J Pulm Crit Care. 2013;6(6):308. doi: http://dx.doi.org/10.13175/swjpcc086-13 PDF