Time Kinetics of Viral Clearance and Resolution of Symptoms in Novel Coronavirus Infection
Tuesday, March 31, 2020 at 9:49AM Chang D, Mo G, Yuan X, Tao Y, Peng X, Wang F, Xie L, Sharma L, Dela Cruz CS, Qin E. Am J Respir Crit Care Med. 2020 Mar 23. [Epub ahead of print] [CrossRef] [PubMed]
The authors briefly describe the time kinetics of symptom onset, duration of symptoms and viral clearance is in 16 patients with COVID-19. The median age was 35.5 years (range 3-68 years), with 11/16 males. The major symptoms in these patients were fever (14/16), cough (11/16), pharyngalgia (5/16) and dyspnea (2/16). The mean incubation period was 5 days (IQR 1-6 days). The mean duration of symptoms was estimated to be 8 days (IQR 6.25-11.5). Most importantly, half (8/16) of the patient remained viral positive (a surrogate marker of shedding) even after the resolution of symptoms (Median 2.5 days, range 1 to 8 days).
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