Correct!
1. Amyloidosis

The “brick red” staining on the Congo red stain indicates the presence of amyloid. In situ hybridization showed the presence of lambda chain plasma cells (Figure 6).

Figure 6. In situ hybridization for lambda chain positive cells.

What should be done next? (Click on the correct answer to be directed to the fifth of six pages)

1. Daratumumab in combination with bortezomib, cyclophosphamide, and dexamethasone
2. Begin mycophenolate
3. Begin prednisone 30 mg daily
4. Observation with follow-up
5. Total body MRI to search for underlying malignancy

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