Correct!
5. All of the above

The Jervell and Lange-Nielsen syndrome and the Romano Ward syndrome are congenital abnormalities associated with QT prolongation and sudden death. The former is associated with congenital deafness while the later is not. A number of drugs have been associated with QT prolongation and torsades, most recently macrolide antibiotics (3).

Our patient was conscious post-arrest and her vital signs were stable. 12-Lead electrocardiogram revealed slight ST-elevation in the anteroseptal leads that resolved within an hour but no QT prolongation. Transthoracic echocardiogram showed no obvious wall motion abnormality. Cardiac MRI and cardiac CT angiography were negative for abnormalities. Eventually, she underwent cardiac catheterization and was found to have spontaneous coronary artery dissection (SCAD) in the left main coronary artery, the mid left anterior descending coronary artery, and involvement of the left circumflex coronary artery as well (Figure 2).

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Figure 2. Panels A-C: Static views of the coronary angiogram showing narrowing from the coronary artery dissection of the left main (Panel A), anterior descending (Panel B) and cirumflex coronary arteries (Panel C). Right panel: video of coronary angiography (be patient-the file is large and depending on your computer and browser may take some time to open).

Which of the following have been associated with spontaneous coronary artery dissection? (Click on the correct answer to proceed to the fourth and final panel)

  1. Cocaine
  2. Ehlers-Danlos syndrome
  3. Fibromuscular dysplasia
  4. 1 and 3
  5. All of the above

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