Correct!
1. The most common hereditary thrombophilia in the US is Factor V Leiden
Testing for thrombophilias should only be performed when results will be used to improve or modify management (5). Testing has been suggested to assist with secondary prevention (determining the duration of anticoagulation following a thrombotic event); and for hereditary disorders, to aid in primary prevention in relatives of affected patients
The patient did well in ICU and was about to be transferred to the floor when she suddenly developed cardiovascular collapse. Cardiopulmonary resuscitation (CPR) was unsuccessful and the patient expired. An autopsy showed a saddle pulmonary embolus.
References
- Ohgi S, Tachibana M, Ikebuchi M, Kanaoka Y, Maeda T, Mori T. Pulmonary embolism in patients with isolated soleal vein thrombosis. Angiology. 1998 Sep;49(9):759-64. [CrossRef] [PubMed]
- Henry JC, Satiani B. Calf muscle venous thrombosis: a review of the clinical implications and therapy. Vasc Endovascular Surg. 2014 Jul-Aug;48(5-6):396-401. [CrossRef] [PubMed]
- Stevens SM, Woller SC, Kreuziger LB, et al. Antithrombotic Therapy for VTE Disease: Second Update of the CHEST Guideline and Expert Panel Report. Chest. 2021 Dec;160(6):e545-e608. [CrossRef] [PubMed]
- Sutanto H, Soegiarto G. Risk of Thrombosis during and after a SARS-CoV-2 Infection: Pathogenesis, Diagnostic Approach, and Management. Hematol Rep. 2023 Apr 3;15(2):225-243. [CrossRef] [PubMed]
- Stevens SM, Woller SC, Bauer KA, et al. Guidance for the evaluation and treatment of hereditary and acquired thrombophilia. J Thromb Thrombolysis. 2016 Jan;41(1):154-64. [CrossRef] [PubMed]
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