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1. Biopsy of the omental thickening

Given the situation, pursuing a diagnosis is indicated. The omental biopsy is easiest although a VATS lung biopsy is reasonable. Repeating the bronchoscopy with transbronchial biopsy seems unlike to be diagnostic. Ultimately, the patient then underwent CT-guided biopsy of the omental thickening due to the ill-defined nature of the mass. Representative pathology slides are shown in Figure 4.

Figure 4. Representative slides from CT-guided biopsy of an ill-defined mass infiltrating the omentum in our patient revealed a chronic inflammatory infiltrate composed of lymphocytes and histiocytes on hematoxylin and eosin (H&E) stain (A, 20x magnification). Rare yeast are highlighted with a Grocott’s Methenamine Silver (GMS) stain, including occasional yeast with narrow based budding (B, arrow head, 40x magnification). To view Figure 4 in a separate, enlarged window click here.

Pathological analysis showed occasional small yeast with narrow based budding. Which of the following fungi could be most compatible with the above pathological analysis? (Click on the correct answer to be directed to the sixth of seven pages)

  1. Aspergillus
  2. Mucorales
  3. Candida
  4. Histoplasma
  5. Malassezia

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