Correct!
4. Dieulafoy’s disease


Dieulafoy’s lesion is a developmental vascular malformation usually seen in the gastrointestinal tract but occasionally the lungs. It is an enlarged submucosal blood vessel that bleeds in the absence of any abnormality, such as ulcers or erosions. Dieulafoy's lesion may cause a nodular endobronchial appearance, but often a white “cap” may be seen, the mucosal may be congested, and tortuous dilated submucosal blood vessels may be evident. The latter contribute to hemoptysis when present, and this patient never complained of such. The other lesions listed may result in an endobronchial nodular appearance as seen in this patient, and the visual appearance of these lesions may be similar.
The bronchoscopic biopsy revealed histologic feature consistent with carcinoid tumor. The patient underwent video-assisted left lower lobe resection with pathologic confirmation of carcinoid tumor. Her Cushing syndrome subsequently resolved.
Diagnosis: Endobronchial carcinoid tumor causing recurrent Cushing syndrome

References

  1. Benson RE, Rosado-de-Christenson ML, Martínez-Jiménez S, Kunin JR, Pettavel PP. Spectrum of pulmonary neuroendocrine proliferations and neoplasms. Radiographics. 2013 Oct;33(6):1631-49. [CrossRef] [PubMed]
  2. Lindner T, Loktev A, Altmann A, et al. Development of Quinoline-Based Theranostic Ligands for the Targeting of Fibroblast Activation Protein. J Nucl Med. 2018 Sep;59(9):1415-1422. [CrossRef] [PubMed]
  3. Kratochwil C, Flechsig P, Lindner T, et al. 68Ga-FAPI PET/CT: Tracer Uptake in 28 Different Kinds of Cancer. J Nucl Med. 2019 Jun;60(6):801-805. [CrossRef] [PubMed]
  4. Caplin ME, Baudin E, Ferolla P, et al. Pulmonary neuroendocrine (carcinoid) tumors: European Neuroendocrine Tumor Society expert consensus and recommendations for best practice for typical and atypical pulmonary carcinoids. Ann Oncol. 2015 Aug;26(8):1604-20. [CrossRef] [PubMed]

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