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4. Squamous cell carcinoma
Biopsy specimens from the right pleural surface and right lower lobe showed sheets of monotonous small to medium-sized neoplastic cells with vesicular nuclei in a background of tumor necrosis and acute inflammation. Multiple areas demonstrated abrupt transition to well-differentiated squamous cell nests (Figure 6).
Figure 6. Histology showing well-differentiated. squamous cell nests.
Tumor cells were diffusely and strongly positive for p40 (squamous differential marker) and NUT (nuclear protein in testis) marker. Genetic testing confirmed a fusion event between the BRD4 and NUTM1 genes.
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