Correct!
5. All of the above

After repeatedly warning against repeated biopsies, it seems almost hypocritical to now recommend a biopsy of the lung nodules and lymph nodes. However, the detection of the new nodules suggests the possibility of a new disease process. Bronchoscopy with endobronchial ultrasound was performed with biopsy of 4R, 7 and 10R lymph node stations. The histology showed poorly differentiated sarcoma, possibly of endothelial origin. This was similar to the pathology on the outside biopsy of the parotid gland. An extended panel for myositis-related antibodies demonstrated the presence of anti-U2 RNP (ribonuclear) antibody, supporting a diagnosis of dermatomyositis.
A diagnosis of amyopathic dermatomyositis with rapidly progressive interstitial lung disease (ILD) was made.

Which of the following are true regarding amyopathic dermatomyositis? (Click on the correct answer to be directed to the seventh and final page)

1. ILD is seen in 60-80% of patients with DM/PM
2. Lung histologic findings can include NSIP, UIP, organizing pneumonia (OP) and diffuse alveolar damage (DAD)
3. Dermatomyositis is associated with a 6-fold higher risk of malignancy than the general population. 
4. 1 and 3
5. All of the above

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