Correct!

5. All of the above

There are a number of carcinomas and sarcomas associated with metastatic cystic lung disease (Table 2).

Table 2. Carcinomas/sarcomas associated with cystic lung metastases.

• Head and neck squamous cell carcinoma
• Seminoma
• Ewing’s sarcoma
• Wilm’s tumor
• Osteogenic sarcoma
• Angiosarcoma
• Transitional cell carcinoma
• Sarcoma of unknown type

Special staining for S100 and HMB 45 was negative but staining for estrogen receptor (ER), smooth muscle actin (SMA), desmin, and CD10 was positive (Figure 7).

Figure 7. Special stains showing positivity for estrogen receptor (ER), smooth muscle actin (SMA), desmin, and CD10.

The pathologists opined that the tumor was most likely due to metastatic spindle cell carcinoma from the uterus based on the histopathology and the special stains (5).

References

1. Ferreira Francisco FA, Soares Souza A Jr, Zanetti G, Marchiori E. Multiple cystic lung disease. Eur Respir Rev. 2015 Dec;24(138):552-64. [CrossRef] [PubMed]
2. Gupta N, Vassallo R, Wikenheiser-Brokamp KA, McCormack FX. Diffuse Cystic Lung Disease. Part I. Am J Respir Crit Care Med. 2015 Jun 15;191(12):1354-66. [CrossRef] [PubMed]
3. Gupta N, Vassallo R, Wikenheiser-Brokamp KA, McCormack FX. Diffuse Cystic Lung Disease. Part II. Am J Respir Crit Care Med. 2015 Jul 1;192(1):17-29. [CrossRef] [PubMed]
4. Raoof S, Bondalapati P, Vydyula R, et al. Cystic Lung Diseases: Algorithmic Approach. Chest. 2016 Oct;150(4):945-965. [CrossRef] [PubMed]
5. Surbhi, Metgud R, Naik S, Patel S. Spindle cell lesions: A review on immunohistochemical markers. J Cancer Res Ther. 2017 Jul-Sep;13(3):412-418. [CrossRef] [PubMed]

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