Correct!
5. All of the above

A number of diseases have been associated with elevated IgE levels and can be broadly grouped as below in Table 1.

Table 1. Disorders associated with elevated IgE levels

Infections: Parasitic, HIV, Mycobacterium Tb, fungal (cocci), CMV
Atopic Disease: Asthma, ABPA, Atopic Dermatitis
Immunodeficiencies: Hyperimmunoglobulin E syndrome, Wiskott-Aldrich Syndrome
Inflammatory Disease: Churg-Strauss, Kimura disease
Neoplasms: Hodgkin’s lymphoma, IgE myeloma
Other: Cystic fibrosis, nephrotic syndrome

Our patient had no evidence of asthma and a sweat chloride for cystic fibrosis was negative.

Which of the following is the likely cause of his elevated IgE? (Click on the correct answer to proceed to the next panel)

1. Hyperimmunogloublin E syndrome
   
2. IgE myeloma
   
3. Kimura disease
   
4. Strongyloidiasis
   
5. Wiskott-Aldrich syndrome

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