Correct!
2. Yes

The sensitivities of TB testing vary depending on the CD4 count (Table 2, 5).

Table 2. Sensitivities of TB testing with low (< 200 mm3) and high (> 200 mm3) CD4 counts.

Nucleic acid amplification is 95.5% sensitive for positive sputum smears and 70% sensitive for negative sputum smears (5).

Now that the presumptive diagnosis of TB has been made, therapy should be initiated.

Since the patient has HIV and has been on isoniazid monotherapy since 2018 what medication adjustments must you make? (Click on the correct answer to be directed to the sixth and final page)

1. No changes are necessary.
2. Rifampin, isoniazid, pyrizinamide, ethambutol, Biktarvy.
3. Rifampin, pyrizinamide, ethambutol, levofloxacin, continue Biktarvy.
4. Rifampin, pyrizinamide, ethambutol, streptomycin, continue Biktarvy.
5. Rifampin, pyrizinamide, ethambutol, levofloxacin, hold Biktarvy for four weeks.

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