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1. HRCT shows multifocal bilateral areas of lobular low attenuation on inspiratory imaging and air trapping on post-expiratory imaging

HRCT shows bilateral inhomogeneous lung attenuation, with areas of both increased attenuation and decreased attenuation. Note that the areas of low attenuation have a somewhat geographic and lobular appearance, and that these particular areas have relatively small-appearing pulmonary vessels compared to the areas of higher attenuation. Furthermore, the areas of low attenuation fail to appropriately increase, and paradoxically actually decrease, in attenuation on post-expiratory imaging- this finding is characteristic of air trapping. The areas of relatively increased appearing attenuation do not represent actual ground-glass opacity- they are merely more normal lung contrasted against the areas of low attenuation, which represent mosaic perfusion. No nodules are present. The large airways show normal wall thickness and caliber- no bronchiectasis is seen and no consolidation is evident.

Based on the information thus far, what is the most likely diagnosis? (Click on the correct answer to proceed to the sixth of seven panels)

  1. Bronchiolitis obliterans
  2. Congenital cystic pulmonary airway malformation
  3. Congenital lobar overinflation / emphysema
  4. Emphysema
  5. None of the above

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