Correct!
1. Genetic mutations affect osteoblast and osteoclasts leading to high bone mineral density and decreased fracture risk
Osteogenesis imperfecta (OI) does have genetic mutations affecting osteoblasts and osteoclasts, but it is associated with low bone density leading to a higher incidence of fractures, scoliosis, short stature, long bone length discrepancies and bowing of long bones. OI is associated with chest wall deformities such as scoliosis, pectus carinatum, pectus excavatum, barrel chest along with rib and vertebral fractures. These chest wall deformities can lead to restrictive lung disease.
The other statements regarding osteogenesis imperfecta are true. Osteogenesis imperfecta has a broad range of severity ranging from fractures in utero to normal adult stature with low fracture incidence as well as variable extra skeletal manifestations.
Our patient is in danger of requiring intubation and mechanical ventilation. What potential risks are associated with intubation in patients who have osteogenesis imperfecta? (Click on the correct answer to be directed to the fifth of seven pages)