Morgan Wong, DO
Nicholas Villalobos, MD
Department of Internal Medicine
University of New Mexico
Albuquerque, NM USA
Critical Care Case of the Month CME Information
Members of the Arizona, New Mexico, Colorado and California Thoracic Societies and the Mayo Clinic are able to receive 0.25 AMA PRA Category 1 Credits™ for each case they complete. Completion of an evaluation form is required to receive credit and a link is provided on the last panel of the activity.
0.25 AMA PRA Category 1 Credit(s)™
Estimated time to complete this activity: 0.25 hours
Lead Author(s): Morgan Wong, DO. All Faculty, CME Planning Committee Members, and the CME Office Reviewers have disclosed that they do not have any relevant financial relationships with commercial interests that would constitute a conflict of interest concerning this CME activity.
As a result of this activity I will be better able to:
- Correctly interpret and identify clinical practices supported by the highest quality available evidence.
- Will be better able to establsh the optimal evaluation leading to a correct diagnosis for patients with pulmonary, critical care and sleep disorders.
- Will improve the translation of the most current clinical information into the delivery of high quality care for patients.
- Will integrate new treatment options in discussing available treatment alternatives for patients with pulmonary, critical care and sleep related disorders.
Learning Format: Case-based, interactive online course, including mandatory assessment questions (number of questions varies by case). Please also read the Technical Requirements.
CME Sponsor: University of Arizona College of Medicine
Current Approval Period: January 1, 2015-December 31, 2017
Financial Support Received: None
History of Present Illness
A 68-year-old man presented to the emergency department with a one-day history of lower back pain, arthralgias, and malaise. The patient had a previous splenectomy and was concerned about influenza.
Past Medical History, Social History, and Family History
He has a history of osteoarthritis, seasonal allergies, and splenectomy. He is a nonsmoker. Family history is noncontributory.
Upon admission, the patient’s vital signs were notable for a temperature of 35.3 degrees Celsius, blood pressure of 74/44 mmHg, oxygen saturation of 85% on room air with a respiratory rate of 24 breaths per minute. Physical exam was prominent for non-pitting edema of the distal upper and lower extremities, as well as diffuse macular rash of the palms and soles.
- White blood cell count of 6.77 X103 cells/uL
- Hemoglobin of 13.8 gm/dL
- Hematocrit of 43.7%
- Platelet count of 19 x 103 /uL
- Creatinine of 3.0 mg/dL
- CO2 < 10 mmol/L
- Anion gap >18 mmol/L
- Liver function tests
- Alanine aminotransferase (ALT) of 511 U/L
- Aspartate aminotransferase (AST) of 529 U/L
- Total bilirubin of 1.0 mg/dL
- INR of 2.07
- Prothromin time of 22.5 seconds
- Partial thromoboplastin time of 82.3 seconds
- Fibrinogen level was 71 mg/dL
Arterial blood gases
- pH of 6.91
- pCO2 54 mmHg
- pO2 263
- HCO3 of 7.7 mmol/L
Procalcitonin >200 ng/ml.
His blood peripheral smear was examined.
Figure 1: Peripheral blood smear on admission.
Given the results of the preliminary laboratory results and peripheral smear what hematologic abnormality are you most concerned with at this time? (Click on the correct answer to proceed to the second of five pages)
- Autoimmune hemolytic anemia (AIHA)
- Disseminated intravascular coagulopathy (DIC)
- Microangiopathic hemolytic anemia (MAHA)
- Thrombotic thrombocytopenic purpura (TTP)