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Southwest Pulmonary and Critical Care Fellowships
In Memoriam

Mandibular Advancement vs CPAP for Blood Pressure Reduction in Patients with Obstructive Sleep Apnea. Ou Y-H, Colpani JT, Cheong CS, et al. Am J Cardiol. 2024 (Accepted). (4-8-24)

Telemedicine Critical Care Availability and Outcomes Among Mechanically Ventilated Patients. Graves JM, Krings JG, Buss JL, Kallogjeri D, Ofoma UR. J Crit Care. 2024 Mar 23;82:154782. (4-5-24)

Impact Of Ambient Ultrafine Particles On Cause-Specific Mortality In Three German Cities. Am J Respir Crit Care Med. 2023 May 15;207(10):1334-1344. (1-17-24)

Video versus Direct Laryngoscopy for Tracheal Intubation of Critically Ill Adults. Prekker ME, Driver BE, Trent SA, et al. N Engl J Med. 2023 Jun 16. (6-29-23) 

Changes in the Practice of Controlled Hypothermia After Cardiac Arrest in the Past 20 Years. Nielsen N, Friberg H. Am J Respir Crit Care Med. 2023 Apr 27. Epub ahead of print. (6-15-23)

Habitual Firsh Oil Supplenetation and Incident Chronic Obstructive Pulmonary Disease: Data from a Prospective Cohort Study.  Li ZH, Song WQ, Shen D, et al. Clin Nutr. 2022 Oct 8;41(12):2652-2658. (12-1-22)

Novel Bronchoscopic Interventions Appear Promising for Patients with COPD. Bowser AD. Chest Physician. November 3, 2022. (9-29-22).

Sleep Apnea and Incident Unprovoked Venous Thromboembolism: Data from the French Pays de la Loire Sleep Cohort. Trzepizur W, Gervès-Pinquié C, Heude B, et al. ERS 2022 Congress. Presented Sept. 5, 2022. (9-13-22)

Dopamine Use and Its Consequences in the Intensive Care Unit: A Cohort Study Utilizing the Japanese Intensive Care Patient Database.  Suzuki R, Uchino S, Sasabuch Y et al. Crit Care. 2022 Apr2:26(1):90. (6-29-22)

Reduction Of Dietary Sodium to Less Than 100 Mmol in Heart Failure (SODIUM-HF): An International, Open-Label, Randomised, Controlled Trial. Ezekowitz JA, Colin-Ramirez E, Ross H, et al. Lancet. 2022 Apr 1:S0140-6736(22)00369-5. (4-8-22)

Effect of Antiplatelet Therapy on Survival and Organ Support-Free Days in Critically Ill Patients With COVID-19: A Randomized Clinical Trial. REMAP-CAP Writing Committee for the REMAP-CAP Investigators, Bradbury CA, Lawler PR, Stanworth SJ, et al. JAMA. 2022 Mar 22. (3-23-22)

Association Between Dexamethasone Treatment After Hospital Discharge for Patients With COVID-19 Infection and Rates of Hospital Readmission and Mortality. Huang CW, Yu AS, Song H, Park JS, Wu SS, Khang VK, Subject CC, Shen E. JAMA Netw Open. 2022 Mar 1;5(3):e221455. (3-14-22)

Aspirin Use Is Associated with Decreased Mechanical Ventilation, Intensive Care Unit Admission, and In-Hospital Mortality in Hospitalized Patients with Coronavirus Disease 2019. Chow JH, Khanna AK, Kethireddy S, et al. Anesth Analg. 2021 Apr 1;132(4):930-941. (12-18-21)

Mortality Risk Among Patients With COVID-19 Prescribed Selective Serotonin Reuptake Inhibitor Antidepressants. Oskotsky T, Maric I, Tang A, Oskotsky B, Wong RJ, Aghaeepour N, Sirota M, Stevenson DK. JAMA Netw Open. 2021 Nov 1;4(11):e2133090. (11-18-21)

Effectiveness of Covid-19 Vaccines against the B.1.617.2 (Delta) Variant. Lopez Bernal J, Andrews N, Gower C, et al. N Engl J Med. 2021 Jul 21. (7-22-21)

Azithromycin for Community Treatment of Suspected COVID-19 in People at Increased Risk of an Adverse Clinical Course in the UK (PRINCIPLE): A Randomised, Controlled, Open-Label, Adaptive Platform Trial. PRINCIPLE Trial Collaborative Group. Lancet. 2021 Mar 4:S0140-6736(21)00461-X. (3-19-21)

The Lancet Commission on Public Policy and Health in the Trump Era. Himmelstein DU, Woolhandler S, Cooney R, McKee M, Horton R.. Lancet. 2018 Sep 22;392(10152):993-995. (2-19-21)

Effect of High-Dose Zinc and Ascorbic Acid Supplementation vs Usual Care on Symptom Length and Reduction Among Ambulatory Patients With SARS-CoV-2 Infection: The COVID A to Z Randomized Clinical Trial. Thomas S, Patel D, Bittel B, et al. JAMA Netw Open. 2021 Feb 1;4(2):e210369. (2-16-21)

Relationship Between Afternoon Napping and Cognitive Function in the Ageing Chinese Population.Cai H, Su N, Li W, et al. General Psychiatry 2021;34:e100361. (February 2, 2021) 

6-Month Consequences Of COVID-19 in Patients Discharged from Hospital: A Cohort Study. Huang C, Huang L, Wang Y, et al. Lancet. 2021 Jan 16;397(10270):220-232. (January 19, 2021)

Anticoagulation, Bleeding, Mortality, and Pathology in Hospitalized Patients With COVID-19. Nadkarni GN, Lala A, Bagiella E, et al. J Am Coll Cardiol. 2020 Oct 20;76(16):1815-1826. (December 23, 2020)

2021 GOLD Guidelines released. (December 19, 2020)

Are Financial Payments From the Pharmaceutical Industry Associated With Physician Prescribing? A Systematic Review. Mitchell AP, Trivedi NU, Gennarelli RL, Chimonas S, Tabatabai SM, Goldberg J, Diaz LA Jr, Korenstein D. Ann Intern Med. 2020 Nov 24. (December 1, 2020)

Sixty-day Outcomes Among Patients Hospitalized with COVID-19. Chopra V, Flanders SA, O'Malley M, Malani AN, Prescott HC.  Ann Intern Med. 2020 Nov 11. Epub ahead of print. (November 16, 2020)

Association of Peer Comparison Emails with Electronic Health Record Documentation of Cancer Stage by Oncologists. Sinaiko AD, Barnett ML, Gaye M, Soriano M, Mulvey T, Hochberg E. JAMA Netw Open. 2020 Oct 1;3(10):e2015935. (November 13, 2020)

Modeling COVID-19 scenarios for the United States. IHME COVID-19 Forecasting Team.  Nat Med. 2020 Oct 23. Epub ahead of print. (October 26, 2020)

A Randomized Trial Comparing Antibiotics with Appendectomy for Appendicitis. CODA Collaborative, Flum DR, Davidson GH, Monsell SE, et al. N Engl J Med. 2020 Oct 5. Epub ahead of print. (October 8, 2020)

Variation in Acute Care Rehabilitation and 30-Day Hospital Readmission or Mortality in Adult Patients with Pneumonia. Freburger JK, Chou A, Euloth T, Matcho B. JAMA Netw Open. 2020;3(9):e2012979. Published 2020 Sep 1. (September 14, 2020)

Association Between Administration of Systemic Corticosteroids and Mortality Among Critically Ill Patients With COVID-19: A Meta-analysis. WHO Rapid Evidence Appraisal for COVID-19 Therapies (REACT) Working Group, Sterne JAC, Murthy S, et al. [published online ahead of print, 2020 Sep 2]. JAMA. 2020;10.1001/jama.2020.17023. (September 3, 2020) 

Serious Adverse Health Events, Including Death, Associated with Ingesting Alcohol-Based Hand Sanitizers Containing Methanol - Arizona and New Mexico, May-June 2020. Yip L, Bixler D, Brooks DE, et al. MMWR Morb Mortal Wkly Rep. 2020;69(32):1070-1073. Published 2020 Aug 14. (August 20, 2020)

Risk of COVID-19 Among Front-Line Health-Care Workers and The General Community: A Prospective. Cohort Study. Nguyen LH, Drew DA, Graham MS, et al. Lancet Public Health. 2020. Published Online July 31, 2020. (August 3, 2020) 

Symptom Duration and Risk Factors for Delayed Return to Usual Health Among Outpatients with COVID-19 in a Multistate Health Care Systems Network — United States, March–June 2020. Tenforde MW, Kim SS, Lindsell CJ, et al. MMWR Morb Mortal Wkly Rep. ePub: 24 July 2020. (July 28, 2020)

Use of Personal Protective Equipment Against Coronavirus Disease 2019 by Healthcare Professionals in Wuhan, China: Cross Sectional Study. Liu M, Cheng SZ, Xu KW, et al.  BMJ. 2020;369:m2195. Published 2020 Jun 10. (July 20, 2020)

Measurement of Airborne Particle Exposure During Simulated Tracheal Intubation Using Various Proposed Aerosol Containment Devices During the COVID-19 Pandemic. Simpson JP, Wong DN, Verco L, Carter R, Dzidowski M, Chan PY. [published online ahead of print, 2020 Jun 19]. Anaesthesia. 2020;10.1111/anae.15188. (July 15, 2020)

Dual LABA/LAMA Therapy versus LABA or LAMA Monotherapy for COPD: A Systematic Review and Meta-analysis in Support of the American Thoracic Society Clinical Practice Guideline. Mammen MJ, Pai V, Aaron SD, Nici L, Alhazzani W, Alexander PE. Ann Am Thorac Soc. 2020; [published online ahead of print, 2020 Jun 12]. (June 14, 2020)

Acute Pulmonary Embolism and COVID-19. Poyiadji N, Cormier P, Patel PY, et al. Radiology. 2020 May 14:201955. (May 27, 2020)

Hydroxychloroquine or Chloroquine with or Without a Macrolide for Treatment of Covid-19: A Multinational Registry Analysis. Mehra MR, Desai SS, Ruschitzka F, Patel AN. Lancet. May 22, 2020. [Epub ahead of print]. (May 26,2020)

Remdesivir In Adults with Severe COVID-19: A Randomised, Double-Blind, Placebo-Controlled, Multicentre Trial. Wang Y, Zhang D, Du G, et al. Lancet. 2020; 395:1569-78. (May 15, 2020)

Association of Treatment Dose Anticoagulation with In-Hospital Survival Among Hospitalized Patients with COVID-19. Paranjpe I, Fuster V, Lala A, et al. J Am Coll Cardiol. 2020 May 5. pii: S0735-1097(20)35218-9. (May 11, 2019)

Assessment of N95 Respirator Decontamination and Re-Use for SARS-Cov-2. Fischer RJ, Morris DJ, Doremalen N, et al. medRxiv. April 15, 2020. (April 20, 2020)

No Evidence of Clinical Efficacy of Hydroxychloroquine in Patients Hospitalized for COVID-19 Infection with Oxygen Requirement: Results of a Study Using Routinely Collected Data to Emulate a Target Trial. Mahevas M,  Tran V, Roumier M, et al. medRxiv. April 14, 2020. (April 17, 2020).

Compassionate Use of Remdesivir for Patients with Severe Covid-19. Grein J, Ohmagari N, Shin D, et al. N Engl J Med. 2020 Apr 10. [Epub ahead of print] (4-12-20).

Forecasting COVID-19 impact on hospital bed-days, ICU-days, ventilator-days and deaths by US state in the next 4 months. IHME COVID-19 health service utilization forecasting team, Christopher JL Murray. MedRxiv. March 26. (4-2-20).

Time kinetics of viral clearance and resolution of symptoms in novel coronavirus infection. Chang D, Mo G, Yuan X, Tao Y, Peng X, Wang F, Xie L, Sharma L, Dela Cruz CS, Qin E. Am J Respir Crit Care Med. 2020 Mar 23. [Epub ahead of print] (3-29-20).

Are patients with hypertension and diabetes mellitus at increased risk for COVID-19 infection? Lancet Respir Med. 2020 Mar 11. pii: S2213-2600(20)30116-8. (3-25-20)

CT Imaging Features of 2019 Novel Coronavirus (2019-nCoV). Chung M, Bernheim A, Mei X, et al. Radiology. 2020 Feb 4:200230. (2-28-20)

Effect of Obstructive Sleep Apnoea and Its Treatment with Continuous Positive Airway Pressure on the Prevalence of Cardiovascular Events in Patients with Acute Coronary Syndrome (ISAACC Study): A Randomised Controlled Trial. Sánchez-de-la-Torre M, Sánchez-de-la-Torre A, Bertran S, et al; on behalf of the Spanish Sleep Network. [published online December 12, 2019]. Lancet Respir Med. (1-8-20)

Changes in Quality of Care after Hospital Mergers and Acquisitions. Beaulieu ND, Dafny LS, Landon BE, Dalton JB, Kuye I, McWilliams JM. N Engl J Med. 2020 Jan 2;382(1):51-9. (1-6-20)

Comparative Effectiveness of Combined Favipiravir A and Oseltamivir Therapy Versus Oseltamivir Monotherapy in Critically Ill Patients with Influenza Virus Infection. Wang Y, Fan G, Salam A, et al. J Infect Dis. 2019 Dec 11. pii: jiz656. (12-17-19)

Balanced Crystalloids Versus Saline in Sepsis: A Secondary Analysis of the SMART Trial. Brown RM, Wang L, Coston TD, et al. Am J Respir Crit Care Med. 2019 Aug 27. (12-13-19)

Association of Aspirin Use with Mortality Risk Among Older Adult Participants in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial. Loomans-Kropp HA1, Pinsky P, Cao Y, Chan AT, Umar A. JAMA Netw Open. 2019 Dec 2;2(12):e1916729. (12-12-19)

Dissecting Racial Bias in an Algorithm Used to Manage the Health of Populations. Obermeyer Z, Powers B, Vogeli C, Mullainathan S. Dissecting racial bias in an algorithm used to manage the health of populations. Science. 2019;366:447-53. (10-25-19)

Dog Ownership and Cardiovascular Health: Results from the Kardiovize 2030 Project. Maugeri A, Medina-Inojosa JR, Kunzova S, Barchitta M, Agodi A, Vinciguerra M, Lopez-Jimenez F. Mayo Clin Proc Innov Qual Outcomes. 2019 Aug 23;3(3):268-275. (9-16-18).

Analysis of Human Performance Deficiencies Associated with Surgical Adverse Events. Suliburk JW, Buck QM, Pirko CJ, Massarweh NN, Barshes NR, Singh H, Rosengart TK. JAMA Netw Open. 2019 Jul 3;2(7):e198067. (8-5-19)

New Drugs: Where Did We Go Wrong and What Can We Do Better? Wieseler B, McGauran N, Kaiser T. BMJ. 2019 Jul 10;366:l4340. (7-20-19)

C-Reactive Protein Testing to Guide Antibiotic Prescribing for COPD Exacerbations. Butler CC, Gillespie D, White P, et al. N Engl J Med. 2019 Jul 11;381(2):111-120. (7-12-19)

Effect of Pressure Support vs T-Piece Ventilation Strategies During Spontaneous Breathing Trials on Successful Extubation Among Patients Receiving Mechanical Ventilation: A Randomized Clinical Trial. Subirà C, Hernández G, Vázquez A. et al. JAMA. 2019;321(22):2175-82. (6-11-19)

Derivation, Validation, and Potential Treatment Implications of Novel Clinical Phenotypes for Sepsis. Seymour CW, Kennedy JN, Wang S, et al. JAMA. 2019 May 19. (5-30-19)

Association of Unrecognized Obstructive Sleep Apnea with Postoperative Cardiovascular Events in Patients Undergoing Major Noncardiac Surgery. Chan MTV, Wang CY, Seet E, et al. JAMA. 2019 May 14;321(18):1788-98. (5-21-19)

CPAP Adherence May Slow 1-Year Cognitive Decline in Older Adults with Mild Cognitive Impairment and Apnea.  Richards KC, Gooneratne N, Dicicco B, et al. J Am Geriatr Soc. 2019 Mar;67(3):558-64. (5-12-19)

Almost Half of Physicians Say EHRs Have Hurt Quality of Care. Frellick M. Medscape. May 01, 2019. (5-2-19)

Early Use of Norepinephrine in Septic Shock Resuscitation (CENSER): A Randomized Trial. Permpikul C, Tongyoo S, Viarasilpa T, Trainarongsakul T, Chakorn T, Udompanturak S. Am J Respir Crit Care Med. 2019 Feb 1. [Epub ahead of print] (4-15-19)

Association of Positive Airway Pressure Prescription with Mortality in Patients with Obesity and Severe Obstructive Sleep Apnea: The Sleep Heart Health Study. Lisan Q, Van Sloten T, Marques Vidal P, Haba Rubio J, Heinzer R, Empana JP. JAMA Otolaryngol Head Neck Surg. 2019 Apr 11. (4-12-19)

Effect of Glucose Improvement on Spirometric Maneuvers in Patients with Type 2 Diabetes: The Sweet Breath Study. Gutiérrez-Carrasquilla L, Sánchez E, Barbé F, et al. Diabetes Care. 2019 Apr;42(4):617-24. (4-12-19)

Whole-Genome Sequencing of Pharmacogenetic Drug Response in Racially Diverse Children with Asthma. Mak ACY, White MJ, Eckalbar WL, et al. Am J Respir Crit Care Med. 2018 Jun 15;197(12):1552-64. (3-26-19)

Patient Safety Outcomes under Flexible and Standard Resident Duty-Hour Rules and Sleep and Alertness in a Duty-Hour Flexibility Trial in Internal Medicine. Silber JH, Bellini LM, Shea JA, et al. N Engl J Med 2019; 380:905-14 and 915-23. (3-7-19)

Factors Associated with High-Quality Guidelines for the Pharmacologic Management of Chronic Diseases in Primary Care: A Systematic Review. Molino CGRC, Leite-Santos NC, Gabriel FC, et al. JAMA Intern Med. 2019 Feb 18. (2-25-19)

Effect of Titrating Positive End-Expiratory Pressure (PEEP) With an Esophageal Pressure-Guided Strategy vs an Empirical High PEEP-Fio2 Strategy on Death and Days Free from Mechanical Ventilation Among Patients With Acute Respiratory Distress Syndrome: A Randomized Clinical Trial. Beitler JR, Sarge T, Banner-Goodspeed VM, et al. JAMA. 2019 Feb 18. [Epub ahead of print] (2-21-19)

Prevalence, Underlying Causes, and Preventability of Sepsis-Associated Mortality in US Acute Care Hospitals. Rhee C, Jones TM, Hamad Y, et al. JAMA Netw Open. 2019 Feb 1;2(2):e187571. (2-19-19)

Early Use of Norepinephrine in Septic Shock Resuscitation (CENSER): A Randomized Trial. Permpikul C, Tongyoo S, Viarasilpa T, Trainarongsakul T, Chakorn T, Udompanturak S. Am J Respir Crit Care Med. 2019 Feb 1 [Epub ahead of print].  (2-4-19)

A Randomized Trial of E-Cigarettes versus Nicotine-Replacement Therapy. Hajek P, Phillips-Waller A, Przulj D, et al. N Engl J Med. 2019 Jan 30. [Epub ahead of print]. (1-31-19)

Pantoprazole in Patients at Risk for Gastrointestinal Bleeding in the ICU. Krag M, Marker S, Perner A, et al. N Engl J Med. 2018 Dec 6;379(23):2199-2208. (1-30-19)

Comparison of Wait Times for New Patients Between the Private Sector and United States Department of Veterans Affairs Medical Centers. Penn M, Bhatnagar S, Kuy S, Lieberman S, Elnahal S, Clancy C, Shulkin D. JAMA Netw Open. 2019 Jan 4;2(1):e187096. (1-21-19)  

The Importance of Smoking Cessation on Surgical Outcome in Primary Lung Cancer. Fukui M, Suzuki K, Matsunaga T, Oh S, Takamochi K. Ann Thorac Surg. 2019 Jan 2. pii: S0003-4975(18)31871-X. (1-20-19)

FDA Warns About Increased Risk of Ruptures or Tears in the Aorta Blood Vessel With Fluoroquinolone Antibiotics in Certain Patients. US Food and Drug Administration. December 20, 2018. (12/22/18).

Optimizing Home Oxygen Therapy. An Official American Thoracic Society Workshop Report. Jacobs SS, Lederer DJ, Garvey CM, et al. Ann Am Thorac Soc. 2018 Dec;15(12):1369-81. (12-13-18)

FDA Approves First Treatment for Lambert-Eaton Myasthenic Syndrome, A Rare Autoimmune Disorder. FDA News Releast. Available at: https://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm627093.htm (12-4-18)

Does Point-of-Care Ultrasonography Improve Clinical Outcomes in Emergency Department Patients with Undifferentiated Hypotension? Atkinson PR, Milne J, Diegelmann L, et al. Ann Emerg Med. 2018 Oct;72(4):478-89. (11-8-18)

E-cigarette Use and Subsequent Smoking Frequency Among Adolescents. Barrington-Trimis JL, Kong G, Leventhal AM, et al. Pediatrics. November 05, 2018. [Epub ahead of print] (11-5-18)

Changes in Prevalence of Health Care-Associated Infections in U.S. Hospitals. Magill SS, O'Leary E, Janelle SJ, et al. N Engl J Med. 2018 Nov 1;379(18):1732-1744. (11-1-18)

Benefits and Harms of Antihypertensive Treatment in Low-Risk Patients with Mild Hypertension. Sheppard JP, Stevens S, Stevens R, Martin U, Mant J, Hobbs FDR, McManus RJ. JAMA Intern Med. October 29, 2018. (11-30-18)

Prevalence of Financial Conflicts of Interest Among Authors of Clinical Guidelines Related to High-Revenue Medications. Khan R, Scaffidi MA, Rumman A, Grindal AW, Plener IS, Grover SC. JAMA Intern Med. 2018 Oct 29. and Evaluation of Industry Relationships Among Authors of Clinical Practice Guidelines in Gastroenterology. CombsTR, Scott J, Jorski A, Heavener T, Vassar M. JAMA Intern Med. 2018 Oct 29. (10-30-18).

Baloxavir Marboxil for Uncomplicated Influenza in Adults and Adolescents. Hayden FG, Sugaya N, Hirotsu N, et al. N Engl J Med. 2018 Sep 6;379(10):913-23. (10-25-18)

Assessment of Industry Data on Pulmonary and Immunosuppressive Effects of IQOS. Moazed F, Chun L, Matthay MA, Calfee CS, Gotts J.. Tob Control. 2018 Aug 29. pii: tobaccocontrol-2018-054296. [Epub ahead of print] (9-24-18)

Effect of Aspirin on All-Cause Mortality in the Healthy Elderly. McNeil JJ, Nelson MR, Woods RL, et al. Effect of aspirin on all-cause mortality in the healthy elderly. N Engl J Med. 2018 Sep 16. [Epub ahead of print] (9-20-18)

Improved Empirical Antibiotic Treatment of Sepsis After an Educational Intervention: The ABISS-Edusepsis Study. Ferrer R, Martínez ML, Gomà G, et al. Crit Care. 2018 Jun 22;22(1):167. (8-31-18).

Effect of Azithromycin on Airflow Decline-Free Survival After Allogeneic Hematopoietic Stem Cell Transplant: The ALLOZITHRO Randomized Clinical Trial. Bergeron A, Chevret S, Granata A, et al. JAMA 2017;318(6):557-566. (8-8-18)

Depression, Antidepressant Use, and Risk of Venous Thromboembolism: Systematic Review and Meta-Analysis Of Published Observational Evidence. Kunutsor SK Seidu S, Khunti K. Ann Med. 2018 Jul 12:1-17. (7-30-18)

Electronic Health Records Associated with Lower Hospital Mortality After Systems Have Time to Mature. Lin SC, Jha AK, Adler-Milstein J. Health Aff (Millwood). 2018 Jul;37(7):1128-1135. (7-12-18)

Sodium Bicarbonate Therapy for Patients with Severe Metabolic Acidaemia in the Intensive Care Unit (BICAR-ICU): A Multicentre, Open-Label, Randomised Controlled, Phase 3 Trial. Jaber S, Paugam C, Futier E, et al. Lancet. 2018 Jun 14. pii: S0140-6736(18)31080-8. (7-6-18)

Combined Analysis of Asthma Safety Trials of Long-Acting β2-Agonists. Busse WW, Bateman ED, Caplan AL, Kelly HW, O'Byrne PM, Rabe KF, Chinchilli VM. N Engl J Med. 2018 Jun 28;378(26):2497-2505. (7-5-18)

Continuity of Care with Doctors-A Matter of Life and Death? A Systematic Review of Continuity of Care and Mortality. Pereira Gray D, Sidaway-Lee K, White E, Thorne A, Evans PH. BMJ Open. 2018 Jun 28;8(6):e021161. (7-3-18)

Minimally Invasive Lung Cancer Surgery Performed by Thoracic Surgeons as Effective as Thoracotomy. Boffa DJ, Kosinski AS, Furnary AP, et al. J Clin Oncol. 2018 May 23:JCO2018778977. [Epub ahead of print] (6-30-18)

Serotonergic Antidepressant Use and Morbidity and Mortality Among Older Adults with COPD. Vozoris NT, Wang X, Austin PC, et al. Eur Respir J  2018 Jun 26. [Epub ahead of print] (6-27-18)

Associations Between American Board of Internal Medicine Maintenance of Certification Status and Performance on a Set of Healthcare Effectiveness Data and Information Set Process Measures. Gray B, Vandergrift J, Landon B, Reschovsky J, Lipner R. Ann Intern Med. 2018 Jun 12. [Epub ahead of print] (6-17-18)

Effects on Abstinence of Nicotine Patch Treatment Before Quitting Smoking: Parallel, Two Arm, Pragmatic Randomised Trial. The preloading investigators. BMJ. 2018 Jun 13;361:k2164. (6-15-18)

Associations Between American Board of Internal Medicine Maintenance of Certification Status and Performance on a Set of Healthcare Effectiveness Data and Information Set Process Measures. Gray B, Vandergrift J, Landon B, Reschovsky J, Lipner R. Ann Intern Med. 2018. June 11, 2018. [Epub ahead of print] (6-12-18)

Impact of Primary Care Intensive Management on High-Risk Veterans' Costs and Utilization: A Randomized Quality Improvement Trial. Yoon J, Chang E, Rubenstein LV, Park A, Zulman DM, Stockdale S, Ong MK, Atkins D, Schectman G, Asch SM. Ann Intern Med. 2018 Jun 5. [Epub ahead of print] (6-7-18)

Effect of Increased Inpatient Attending Physician Supervision on Medical Errors, Patient Safety, and Resident Education: A Randomized Clinical Trial. Finn KM, Metlay JP, Chang Y, Nagarur A, Yang S, Landrigan CP, Iyasere C.JAMA Intern Med. 2018 Jun 4 [Epub ahead of print]. (6-6-18)

Adjuvant Chemotherapy Guided by a 21-Gene Expression Assay in Breast Cancer. Sparano JA, Gray RJ, Makower DF, et al. N Engl J Med. 2018; June 3. (6-4-18)

Effect of Use of a Bougie vs Endotracheal Tube and Stylet on First-Attempt Intubation Success Among Patients with Difficult Airways Undergoing Emergency Intubation: A Randomized Clinical Trial. Driver BE, Prekker ME, Klein LR, Reardon RF, Miner JR, Fagerstrom ET, Cleghorn MR, McGill JW, Cole JB. JAMA. 2018 May 16. (6-1-18)

Association of Pharmaceutical Industry Marketing of Opioid Products to Physicians With Subsequent Opioid Prescribing. Hadland SE, Cerdá M, Li Y, Krieger MS, Marshall BDL. JAMA Int Med 2018; May 14. [Epub ahead of print] (5-14-18)

Low-Dose CT for the Diagnosis of Pneumonia in Elderly Patients: A Prospective, Interventional Cohort Study. Prendki V, Scheffler M, Huttner B, et al. Eur Respir J. 2018 Apr 12. pii: 1702375. [Epub ahead of print] (5-4-18)

Nivolumab plus Ipilimumab in Lung Cancer with a High Tumor Mutational Burden. Hellmann MD, Ciuleanu TE, Pluzanski A, et al. N Engl J Med. 2018 Apr 16 [Epub ahead of print] (4-17-18)

Four-gene Pan-African Blood Signature Predicts Progression to Tuberculosis. Suliman S, Thompson E, Sutherland J, et al. Am J Respir Crit Care Med. 2018 Apr 6. [Epub ahead of print] (4-10-18)

A Time-Motion Study of Primary Care Physicians' Work in the Electronic Health Record Era. Young RA, Burge SK, Kumar KA, Wilson JM, Ortiz DF. Fam Med. 2018 Feb;50(2):91-9. (3-28-18)

Impact of Temporary Methotrexate Discontinuation for 2 Weeks on Immunogenicity of Seasonal Influenza Vaccination in Patients with Rheumatoid Arthritis: A Randomised Clinical Trial. Park JK, Lee YJ, Shin K, Ha YJ, et al.  Ann Rheum Dis. 2018 Mar 23. pii: annrheumdis-2018-213222. (3-27-18)

Quantifying Population-Level Health Benefits and Harms of E-Cigarette Use in the United States. Soneji SS, Sung HY, Primack BA, Pierce JP, Sargent JD. PLoS One. 2018 Mar 14;13(3):e0193328. (3-15-18)

Effect of opioid vs nonopioid medications on pain-related function in patients with chronic back pain or hip or knee osteoarthritis pain: The SPACE randomized clinical trial. Krebs EE, Gravely A, Nugent S, et al. JAMA. 2018 Mar 6;319(9):872-82. (3-6-18)

Adolescent Exposure to Toxic Volatile Organic Chemicals from E-Cigarettes. Rubinstein ML, Delucchi K, Benowitz NL, et al. Pediatrics. 2018;141(4):e20173557. (3/5/18)

Electronic Cigarette Use and Progression from Experimentation to Established Smoking. Chaffee BW, Watkins SL, Glantz SA. Pediatrics. 2018;141(4):e20173594. (3/5/18)

Association of Cigarette, Cigar, and Pipe Use With Mortality Risk in the US Population. Christensen CH, Rostron B, Cosgrove C, et al. Association of Cigarette, Cigar, and Pipe Use With Mortality Risk in the US Population. JAMA Intern Med. 2018 Feb 19. [Epub ahead of print] (2-22-18)

Cleaning at Home and at Work in Relation to Lung Function Decline and Airway Obstruction. Svanes Ø, Bertelsen RJ, Lygre SH, et al.  Am J Respir Crit Care Med. 2018 Feb 16. [Epub ahead of print] (2-20-18)

Long-term Use of Inhaled Corticosteroids in COPD and the Risk of Fracture. Gonzalez AV, Coulombe J, Ernst P, Suissa S. Chest. 2018;153(2):321-8. (2-15-18)

Prevention of Ventilator-Associated Pneumonia: The Multimodal Approach of the Spanish ICU “Pneumonia Zero” Program.  Álvarez-Lerma F, Palomar-Martínez M, Sánchez-García M, et al. Crit Care Med 2018;46:181-8. (2-8-18) 

Progressive Massive Fibrosis in Coal Miners From 3 Clinics in Virginia. Blackley DJ, Reynolds LE, Short C, Carson R, Storey,E, Halldin,CN, Laney AS. JAMA 2018;319(5):50-1. (2-6-18)

Low cigarette consumption and risk of coronary heart disease and stroke: meta-analysis of 141 cohort studies in 55 study reports. Hackshaw A,  Morris JK, Boniface S, Tang JL, Milenković D. BMJ. 2018;360:j5855. (1-27-18)

Comparison of observed harms and expected mortality benefit for persons in the veterans health affairs lung cancer screening demonstration project. Caverly TJ, Fagerlin A, Wiener RS, Slatore CG, Tanner NT, Yun S, Hayward R. JAMA Intern Med. 2018 Jan 22. [Epub ahead of print] (1-22-18)

Risk of thromboembolism in cisplatin versus carboplatin-treated patients with lung cancer. Kim ES, Baran AM, Mondo EL, et al. PLoS One. 2017 Dec 11;12(12):e0189410. (1-8-18)

Association of cardiovascular risk with inhaled long-acting bronchodilators in patients with chronic obstructive pulmonary disease: A nested case-control study. Wang MT, Liou JT, Lin CW, Tsai CL, Wang YH, Hsu YJ, Lai JH. JAMA Intern Med. 2018 Jan 2. [Epub ahead of print] (1-5-18)

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Previously selected articles that were thought important but had received little attention were summarized under our “News” section. However, the work of publication (review, DOAJ, doi, social media, etc.) has become too arduous to do justice to these publications. Therefore, we are beginning a new section titled “News from Other Journals” where selected articles are briefly summarized. Important articles that are published in journals commonly read by pulmonologists, intensivists or sleep physicians will not necessarily be reviewed but articles that are in general medicine journals or lower impact journals that might be of interest to the practicing physician are selected. As always, there will be links to the article via CrossRef and/or PubMed.

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Tuesday
Feb022021

Relationship Between Afternoon Napping and Cognitive Function in the Ageing Chinese Population

Cai H, Su N, Li W, et al. General Psychiatry 2021;34:e100361. [CrossRef]

Background Several studies have shown that afternoon napping promotes cognitive function in the elderly; on the other hand, some studies have shown opposite results. This current study further examined the relationship between afternoon napping and cognitive function in the ageing Chinese population.

Methods A total of 2214 elderly were included (napping group: n=1534; non-napping group: n=680). They all received cognitive evaluations by the Beijing version of the Montreal Cognitive Assessment, the Mini-Mental State Examination, and the Chinese version of the Neuropsychological Test Battery. Among all the subjects, 739 elderly volunteered to take blood lipid tests.

Results Significant differences in cognitive function and blood lipids were observed between the napping and the non-napping groups. Afternoon napping was associated with better cognitive function including orientation, language, and memory in the present study. Subjects with the habit of afternoon napping also showed a higher level of triglyceride than the non-napping subjects.

Conclusion The results demonstrated that afternoon napping was related to better cognitive function in the Chinese ageing population.

I am often asked by patients or spouses about daytime naps. Usually, I give a flip answer something like, "It's an old man's perogrative". This manuscript gives some assurance that it is not abnormal and might even be good. 

Tuesday
Jan192021

6-Month Consequences Of COVID-19 in Patients Discharged from Hospital: A Cohort Study

Huang C, Huang L, Wang Y, et al. Lancet. 2021 Jan 16;397(10270):220-232. [CrossRef] [PubMed]

The long-term health consequences of COVID-19 remain largely unclear. In the largest follow-up study of COVID-19 patients 1733 of 2469 discharged patients with COVID-19 from Wuhan, China were enrolled after 736 were excluded. Patients had a median age of 57·0 (IQR 47·0-65·0) years and 897 (52%) were men. The follow-up study was done from June 16, to Sept 3, 2020, and the median follow-up time after symptom onset was 186·0 (175·0-199·0) days. Fatigue or muscle weakness (63%, 1038 of 1655), sleep difficulties (26%, 437 of 1655) and anxiety or depression (23%, 367 of 1617) of patients were the most common symptoms reported. Patients who were more severely ill during their hospital stay had more severe impaired pulmonary diffusion capacities and abnormal chest imaging manifestations, and are the main target population for intervention of long-term recovery. 

Wednesday
Dec232020

Anticoagulation, Bleeding, Mortality, and Pathology in Hospitalized Patients With COVID-19

Nadkarni GN, Lala A, Bagiella E, et al. J Am Coll Cardiol. 2020 Oct 20;76(16):1815-1826. [CrossRef] [PubMed]

The authors retrospectively examined patterns of anticoagulation and effects of these treatments in nearly 4400 adults admitted to New York City hospitals with COVID-19. Of the patients, 45% received prophylactic anticoagulation, 21% received therapeutic anticoagulation, and the remainder received none. Overall, 24% of the patients died in the hospital. After multivariable adjustment, prophylactic and therapeutic treatment were each associated with roughly a 50% reduction in mortality, relative to no anticoagulation. Rates of major bleeding were low (2%–3%). In addition, of 26 autopsies performed, thromboembolic disease was found in 42%; most of these patients had not received therapeutic anticoagulation. These observations would support a prospective, randomized, multi-center study.

Saturday
Dec192020

2021 GOLD Guidelines Released

The 2021 GOLD guidelines have been released. To download the 2021 GOLD Pocket Guide paste the following link into your browser. 

Tuesday
Dec012020

Are Financial Payments From the Pharmaceutical Industry Associated With Physician Prescribing? A Systematic Review

Mitchell AP, Trivedi NU, Gennarelli RL, Chimonas S, Tabatabai SM, Goldberg J, Diaz LA Jr, Korenstein D. Ann Intern Med. 2020 Nov 24. [CrossRef] [PubMed]

Financial payments from the drug industry to U.S. physicians are common and may influence physicians' clinical decision making and drug prescribing. The authors searched MEDLINE (Ovid), Embase, the Cochrane Library, Web of Science, and EconLit for studies examining an association between receipt of industry payments (exposure) and prescribing (outcome). Thirty-six studies comprising 101 analyses were included. Most studies (n = 30) identified a positive association between payments and prescribing in all analyses; the remainder (n = 6) had a mix of positive and null findings. No study had only null findings. Of 101 individual analyses, 89 identified a positive association. Payments were associated with increased prescribing of the paying company's drug, increased prescribing costs, and increased prescribing of branded drugs. Nine studies assessed and found evidence of a temporal association; 25 assessed and found evidence of a dose–response relationship.

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